| http://purl.uniprot.org/citations/19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19540213 | http://www.w3.org/2000/01/rdf-schema#comment | "Tricyclic antidepressant (TCA) drugs are used for the treatment of chronic depression, obsessive-compulsive disorder (OCD), and anxiety-related disorders. Chronic use of TCA drugs increases the expression of alpha(1)-adrenergic receptors (alpha(1)-ARs). Yet, it is unclear whether increased alpha(1)-AR expression contributes to the antidepressant effects of these drugs or if this effect is unrelated to their therapeutic benefit. In this study, mice expressing constitutively active mutant alpha(1A)-ARs (CAM alpha(1A)-AR) or CAM alpha(1B)-ARs were used to examine the effects of alpha(1A)- and alpha(1B)-AR signaling on rodent behavioral models of depression, OCD, and anxiety. CAM alpha(1A)-AR mice, but not CAM alpha(1B)-AR mice, exhibited antidepressant-like behavior in the tail suspension test and forced swim test. This behavior was reversed by prazosin, a selective alpha(1)-AR inverse agonist, and mimicked by chronically treating wild type mice with cirazoline, an alpha(1A)-AR agonist. Marble burying behavior, commonly used to model OCD in rodents, was significantly decreased in CAM alpha(1A)-AR mice but not in CAM alpha(1B)-AR mice. In contrast, no significant differences in anxiety-related behavior were observed between wild type, CAM alpha(1A)-AR, and CAM alpha(1B)-AR animals in the elevated plus maze and light/dark box. This is the first study to demonstrate that alpha(1A)- and alpha(1B)-ARs differentially modulate antidepressant-like behavior in the mouse. These data suggest that alpha(1A)-ARs may be a useful therapeutic target for the treatment of depression."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2009.06.035"xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Rorabaugh B.R."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Jensen K.A."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Talbot J.N."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Doze V.A."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Luger E.J."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Darsie B."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Handel E.M."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/author | "Haselton J.R."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/pages | "148-157"xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/title | "alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse."xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://purl.uniprot.org/core/volume | "1285"xsd:string |
| http://purl.uniprot.org/citations/19540213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19540213 |
| http://purl.uniprot.org/citations/19540213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19540213 |
| http://purl.uniprot.org/uniprot/#_B1AU41-mappedCitation-19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19540213 |
| http://purl.uniprot.org/uniprot/#_P97717-mappedCitation-19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19540213 |
| http://purl.uniprot.org/uniprot/#_P97718-mappedCitation-19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19540213 |
| http://purl.uniprot.org/uniprot/#_Q8BXZ4-mappedCitation-19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19540213 |
| http://purl.uniprot.org/uniprot/#_Q8CGI5-mappedCitation-19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19540213 |
| http://purl.uniprot.org/uniprot/#_Q05D47-mappedCitation-19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19540213 |
| http://purl.uniprot.org/uniprot/#_Q9DBL0-mappedCitation-19540213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19540213 |