| http://purl.uniprot.org/citations/19541636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19541636 | http://www.w3.org/2000/01/rdf-schema#comment | "The inner membrane of the nuclear envelope (NE) was previously shown to contain a Na/Ca exchanger (NCX) tightly linked to GM1 ganglioside that mediates transfer of nucleoplasmic Ca(2+) to the NE lumen and constitutes a cytoprotective mechanism. This transfer was initially observed with isolated nuclei and is now demonstrated in living cells in relation to subcellular Ca(2+) dynamics. Four cell lines with varying expression of NCX and GM1 in the NE were transfected with cameleon-fluorescent Ca(2+) indicators genetically targeted to NE/endoplasmic reticulum (ER) and nucleoplasm to monitor [Ca(2+)](ne/er) and [Ca(2+)](n) respectively. Cytosolic Ca(2+) ([Ca(2+)](cyt)) was indicated with fura-2. Thapsigargin caused progressive loss of [Ca(2+)](ne/er), which was rapidly replaced on addition of extrinsic Ca(2+) to those cells containing fully functional NCX/GM1: differentiated NG108-15 and C6 cells. Reduced elevation of [Ca(2+)](ne/er) following thapsigargin depletion occurred in cells containing little or no GM1 in the NE: undifferentiated NG108-15 and NG-CR72 cells. No change in [Ca(2+)](ne/er) due to applied Ca(2+) was seen in Jurkat cells, which entirely lack NCX. Ca(2+) entry to NE/ER was also blocked by KB-R7943, inhibitor of NCX. [Ca(2+)](n) and [Ca(2+)](cyt) were elevated independent of [Ca(2+)](ne/er) and remained in approximate equilibrium with each other. Ca(2+) rise in the ER originated in the NE region and extended to the entire ER network. These results indicate the nuclear NCX/GM1 complex acts to gate Ca(2+) transfer from cytosol to ER, an alternate route to the sarcoplasmic/endoplasmic reticulum calcium ATPase pump. They also suggest a possible contributory mechanism for independent regulation of nuclear Ca(2+)."xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0903408106"xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/author | "Lu Z.H."xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/author | "Ledeen R.W."xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/pages | "10829-10834"xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/title | "Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum."xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19541636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19541636 |
| http://purl.uniprot.org/citations/19541636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19541636 |
| http://purl.uniprot.org/uniprot/#_Q14913-mappedCitation-19541636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/#_Q4QQH3-mappedCitation-19541636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/#_P32418-mappedCitation-19541636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/#_Q7Z686-mappedCitation-19541636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/#_Q6LAJ8-mappedCitation-19541636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/#_Q6LAJ9-mappedCitation-19541636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/P32418 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/Q14913 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/Q6LAJ9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/Q6LAJ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19541636 |
| http://purl.uniprot.org/uniprot/Q4QQH3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19541636 |