| http://purl.uniprot.org/citations/19543270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19543270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19543270 | http://www.w3.org/2000/01/rdf-schema#comment | "Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is thought to function as an epigenetic mark that specifies centromere identity. Here we identify the essential centromere protein CENP-N as the first protein to selectively bind CENP-A nucleosomes but not H3 nucleosomes. CENP-N bound CENP-A nucleosomes in a DNA sequence-independent manner, but did not bind soluble CENP-A-H4 tetramers. Mutations in CENP-N that reduced its affinity for CENP-A nucleosomes caused defects in CENP-N localization and had dominant effects on the recruitment of CENP-H, CENP-I and CENP-K to centromeres. Depletion of CENP-N using siRNA (short interfering RNA) led to similar centromere assembly defects and resulted in reduced assembly of nascent CENP-A into centromeric chromatin. These data suggest that CENP-N interprets the information encoded within CENP-A nucleosomes and recruits other proteins to centromeric chromatin that are required for centromere function and propagation."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1899"xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1899"xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Carroll C.W."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Carroll C.W."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Straight A.F."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Straight A.F."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Silva M.C.C."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Silva M.C.C."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Jansen L.E.T."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Jansen L.E.T."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Godek K.M."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/author | "Godek K.M."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/pages | "896-902"xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/pages | "896-902"xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/title | "Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/title | "Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N."xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/19543270 | http://purl.uniprot.org/core/volume | "11"xsd:string |