| http://purl.uniprot.org/citations/19544486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19544486 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4(+) T cells are important for CD8(+) T-cell priming by providing cognate signals for DC maturation. We analyzed the capacity of CD4(+) T cells to influence CD8(+) T-cell responses induced by activated DC. Surprisingly, mice depleted for CD4(+) cells were able to generate stronger antigen-specific CD8(+) T-cell responses after DC vaccination than non-depleted mice. The same observation was made when mice were vaccinated with MHC class II(-/-) DC, indicating the presence of a MHC class II-dependent CD4(+) T-cell population inhibiting CD8(+) T-cell responses. Recently we described the expansion of DX5(+)CD4(+) T cells, a T-cell population displaying immune regulatory properties, upon vaccination with DC. Intriguingly, we now observe an inverse correlation between CD8(+) T-cell induction and expansion of DX5(+)CD4(+) T cells as the latter cells did not expand after vaccination with MHC class II(-/-) DC. In vitro, DX5(+)CD4(+) T cells were able to limit proliferation, modulate cytokine production and induce Foxp3(+) expression in OVA-specific CD8(+) T cells. Together, our data show an inhibitory role of CD4(+) T cells on the induction of CD8(+) T-cell responses by activated DC and indicate the involvement of DX5(+)CD4(+), but not CD4(+)CD25(+), T cells in this process."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200838842"xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Camps M."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Franken K.L."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Ossendorp F."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Melief C.J."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Toes R.E."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Huizinga T.W."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Fu N."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Louis-Plence P."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Han W.G."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "Schuurhuis D.H."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/author | "van Duivenvoorde L.M."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/pages | "1765-1773"xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/title | "DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg."xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/19544486 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19544486 |
| http://purl.uniprot.org/citations/19544486 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19544486 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-19544486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19544486 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-19544486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19544486 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-19544486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19544486 |
| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-19544486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19544486 |