| http://purl.uniprot.org/citations/19545928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19545928 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer/testis antigens (CT antigens) are thought to be suitable targets for antigen-specific immunotherapy, because of the cancer-specific expression except for the testis among various normal tissues and no-expression of HLA class I in the testis. In the present study, the expressions of CT antigens (MAGE-A3, MAGE-A4, NY-ESO-1 and KK-LC-1) in non-small cell lung cancer (NSCLC) were analyzed by RT-PCR. The subjects were 239 patients with NSCLC who underwent surgery from 2001 to 2005 in our department. The expression rates of MAGE-A3, MAGE-A4, NY-ESO-1 and KK-LC-1 were 23.8%, 20.1%, 10.5% and 32.6% in patients with NSCLC, respectively. MAGE-A4 was expressed more frequently in male (25.3%) than in female (10.6%) (p<0.01). The positive proportion of MAGE-A4 was higher in stages II-IV (30.6%) than in stage I (12.8%) (p<0.01). Both of MAGE-A3 and MAGE-A4 were expressed more frequently in squamous cell carcinoma than in adenocarcinoma (p<0.01). Such tendency was not observed among NY-ESO-1 and KK-LC-1 expression. KK-LC-1 was expressed in 32.1% of patients with adenocarcinoma and in 36.5% of patients with squamous cell carcinoma. Patients with positive MAGE-A4 expression showed significantly poorer overall survival than those without MAGE-A4 expression (p=0.013), and such effect on survival was also observed, when the analysis was limited to patients at stage I (p=0.0037). Expression of MAGE-A3, NY-ESO-1 or KK-LC-1 did not affect survival of patients with NSCLC significantly, however, expression of at least one of such CT antigens negatively affect survival of patients with NSCLC (p=0.045)."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lungcan.2009.05.010"xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Baba T."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Kuroda K."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Mizukami M."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Yasuda M."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Yasumoto K."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "So T."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Ichiki Y."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Shigematsu Y."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Shiota H."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Hanagiri T."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "So T.'"xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/author | "Takenoyama M."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/name | "Lung Cancer"xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/pages | "105-110"xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/title | "Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/19545928 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19545928 |
| http://purl.uniprot.org/citations/19545928 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19545928 |
| http://purl.uniprot.org/uniprot/#_B4DTE6-mappedCitation-19545928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19545928 |
| http://purl.uniprot.org/uniprot/#_Q4V9T5-mappedCitation-19545928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19545928 |
| http://purl.uniprot.org/uniprot/#_P43358-mappedCitation-19545928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19545928 |