| http://purl.uniprot.org/citations/19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19546217 | http://www.w3.org/2000/01/rdf-schema#comment | "p120 catenin is a major regulator of cadherin stability at cell-cell contacts and a modulator of Rho GTPase activities. In C2C12 myoblasts, N-cadherin is stabilized at cell contacts through its association with cholesterol-rich membrane domains or lipid rafts (LR) and acts as an adhesion-activated receptor that activates RhoA, an event required for myogenesis induction. Here, we report that association of p120 catenin with N-cadherin at cell contacts occurs specifically in LR. We demonstrate that interaction of p120 catenin with N-cadherin is required for N-cadherin association with LR and for its stabilization at cell contacts. LR disruption inhibits myogenesis induction and N-cadherin-dependent RhoA activation as does the perturbation of the N-cadherin-p120 catenin complex after p120 catenin knockdown. Finally, we observe an N-cadherin-dependent accumulation of RhoA at phosphatidylinositol 4,5-bisphosphate-enriched cell contacts which is lost after LR disruption. Thus, a functional N-cadherin-catenin complex occurs in cholesterol-rich membrane microdomains which allows the recruitment of RhoA and the regulation of its activity during myogenesis induction."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.017665"xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/author | "Bodin S."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/author | "Charrasse S."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/author | "Gauthier-Rouviere C."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/author | "Taulet N."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/author | "Comunale F."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/author | "Favard C."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/pages | "23137-23145"xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/title | "N-cadherin/p120 catenin association at cell-cell contacts occurs in cholesterol-rich membrane domains and is required for RhoA activation and myogenesis."xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19546217 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19546217 |
| http://purl.uniprot.org/citations/19546217 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19546217 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWJ1-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXF6-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_E9Q8Z5-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_E9Q8Z6-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_E9Q8Z8-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_E9Q905-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_E9Q986-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_D3YYT0-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |
| http://purl.uniprot.org/uniprot/#_G3X9V2-mappedCitation-19546217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19546217 |