| http://purl.uniprot.org/citations/19546506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19546506 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian epididymis provides sperm with an environment that promotes their maturation and protects them from external stresses. For example, it harbors an array of antioxidants, including non-conventional glutathione peroxidase 5 (GPX5), to protect them from oxidative stress. To explore the role of GPX5 in the epididymis, we generated mice that lack epididymal expression of the enzyme. Histological analyses of Gpx5-/-epididymides and sperm cells revealed no obvious defects. Furthermore, there were no apparent differences in the fertilization rate of sexually mature Gpx5-/-male mice compared with WT male mice. However, a higher incidence of miscarriages and developmental defects were observed when WT female mice were mated with Gpx5-deficient males over 1 year old compared with WT males of the same age. Flow cytometric analysis of spermatozoa recovered from Gpx5-null and WT male mice revealed that sperm DNA compaction was substantially lower in the cauda epididymides of Gpx5-null animals and that they suffered from DNA oxidative attacks. Real-time PCR analysis of enzymatic scavengers expressed in the mouse epididymis indicated that the cauda epididymidis epithelium of Gpx5-null male mice mounted an antioxidant response to cope with an excess of ROS. These observations suggest that GPX5 is a potent antioxidant scavenger in the luminal compartment of the mouse cauda epididymidis that protects spermatozoa from oxidative injuries that could compromise their integrity and, consequently, embryo viability."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci38940"xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Gottwald U."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Kauselmann G."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Damon C."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Kern H."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Drevet J.R."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Zevnik B."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Schoor M."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Lenoir A."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Habenicht U."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Saez F."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Henry-Berger J."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Vernet P."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Cadet R."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Chabory E."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/author | "Garrel C."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/pages | "2074-2085"xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/title | "Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice."xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/19546506 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19546506 |
| http://purl.uniprot.org/citations/19546506 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19546506 |