| http://purl.uniprot.org/citations/19547756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19547756 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes. We have previously shown that IL-1beta synthesis in the hippocampus is dependent on P2X(7) receptor (P2X(7)R), which is an ionotropic receptor of ATP. To substantiate the role of P2X(7)R in both brain IL-1beta expression and memory processes, we examined the induction of IL-1beta mRNA expression in the hippocampus of wild-type (WT) and homozygous P2X(7) receptor knockout mice (P2X(7)R(-/-)) following a spatial memory task. The spatial recognition task induced both IL-1beta mRNA expression and c-Fos protein activation in the hippocampus of WT but not of P2X(7)R(-/-) mice. Remarkably, P2X(7)R(-/-) mice displayed spatial memory impairment in a hippocampal-dependant task, while their performances in an object recognition task were unaltered. Taken together, our results show that P2X(7)R plays a critical role in spatial memory processes and the associated hippocampal IL-1beta mRNA synthesis and c-Fos activation."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0006006"xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/author | "Aubert A."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/author | "Costes L."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/author | "Laye S."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/author | "Ferreira G."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/author | "Darnaudery M."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/author | "Amedee T."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/author | "Labrousse V.F."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/pages | "e6006"xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/title | "Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/19547756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19547756 |
| http://purl.uniprot.org/citations/19547756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19547756 |
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| http://purl.uniprot.org/uniprot/#_C8YIX4-mappedCitation-19547756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19547756 |
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| http://purl.uniprot.org/uniprot/#_Q8CHP3-mappedCitation-19547756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19547756 |
| http://purl.uniprot.org/uniprot/#_Q8CHP4-mappedCitation-19547756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19547756 |