| http://purl.uniprot.org/citations/19549365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19549365 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate the effect of intracellular acidification on the P-gp in K562/A02 cells. Confocal laser microscope was used to determine the intracellular acidification. MTT assay was used to detect the cytotoxicity of intracellular acidification on K562 and K562/A02 cells. Flow cytometry was applied to measure the influence of intracellular acidification on the activity of P-gp. The P-gp expression at protein and mRNA levels were determined by Western blot and real-time RT-PCR respectively. The results indicated that intracellular acidification had no obvious cytotoxicity on K562 and K562/A02 cells. The function of P-gp in K562/A02 cells weakened along with decrease of intracellular acidification, the intracellular acidification significantly increased the accumulation of Rhodamine 123 (Rh 123) and suppressed the efflux of Rh 123 mediated by P-gp. The intracellular acidification also inhibited the expression of P-gp in K562/A02 cells at protein and mRNA levels which showed intracellular acidification with time-dependence. It is concluded that the intracellular acidification can inhibit the expression and function of P-gp in K562/A02 cells."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Li Q.H."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Wang J.X."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Pang T.X."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Ru Y.X."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/author | "Yuan W.S."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/name | "Zhongguo Shi Yan Xue Ye Xue Za Zhi"xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/pages | "568-573"xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/title | "[Effect of intracellular acidification on P-glycoprotein in drug-resistant K562/A02 cells]."xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/19549365 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19549365 |
| http://purl.uniprot.org/citations/19549365 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19549365 |
| http://purl.uniprot.org/uniprot/#_F4ZUY5-mappedCitation-19549365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19549365 |
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| http://purl.uniprot.org/uniprot/#_F4ZUT2-mappedCitation-19549365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19549365 |
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