| http://purl.uniprot.org/citations/19549840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19549840 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular stimuli regulate neuronal differentiation and subtype specification during brain development, although the intracellular signaling pathways that mediate these processes remain largely unclear. We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs). Active Akt promotes differentiation of NPC into gamma-aminobutyric acid-containing (GABAergic) but not glutamatergic neurons. Disruption of the Pdk1 gene or expression of dominant-negative forms of Akt suppresses insulin-like growth factor (IGF)-1 enhancement of NPC differentiation into neurons in vitro and production of neocortical GABAergic neurons in vivo. Furthermore, active Akt increased the protein levels and transactivation activity of Mash1, a proneural basic helix-loop-helix protein required for the generation of neocortical GABAergic neurons, and Mash1 was required for Akt-induced neuronal differentiation. These results have unveiled an unexpected role of the PDK1-Akt pathway: a key mediator of extracellular signals regulating the production of neocortical GABAergic neurons."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0808400106"xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/author | "Gotoh Y."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/author | "Oishi K."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/author | "Itoh Y."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/author | "Nakajima K."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/author | "Okano H."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/author | "Guillemot F."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/author | "Watatani K."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/pages | "13064-13069"xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/title | "Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1."xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19549840 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19549840 |
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