| http://purl.uniprot.org/citations/19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19553679 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon virus infection, the cell mounts an innate type I interferon (IFN) response to limit the spread. This response is orchestrated by the constitutively expressed IFN regulatory factor (IRF)-3 protein, which becomes post-translationally activated. Although the activation events are understood in detail, the negative regulation of this innate response is less well understood. Many viruses, including Kaposi sarcoma-associated herpesvirus (KSHV), have evolved defense strategies against this IFN response. Thus, KSHV encodes a viral IRF (vIRF)-2 protein, sharing homology with cellular IRFs and is a known inhibitor of the innate IFN response. Here, we show that vIRF-2 mediates IRF-3 inactivation by a mechanism involving caspase-3, although vIRF-2 itself is not pro-apoptotic. Importantly, we also show that caspase-3 participates in normal IRF-3 turnover in the absence of vIRF-2, during the antiviral response induced by poly(I:C) transfection. These data provide unprecedented insight into negative regulation of IRF-3 following activation of the type I IFN antiviral response and the mechanism by which KSHV vIRF-2 inhibits this innate response."xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.033290"xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/author | "Blackbourn D.J."xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/author | "Areste C."xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/author | "Mutocheluh M."xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/pages | "23272-23285"xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/title | "Identification of caspase-mediated decay of interferon regulatory factor-3, exploited by a Kaposi sarcoma-associated herpesvirus immunoregulatory protein."xsd:string |
| http://purl.uniprot.org/citations/19553679 | http://purl.uniprot.org/core/volume | "284"xsd:string |
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| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19553679 |
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| http://purl.uniprot.org/uniprot/#_E2GIM7-mappedCitation-19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19553679 |
| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19553679 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19553679 |
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| http://purl.uniprot.org/uniprot/#_M0QYT9-mappedCitation-19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19553679 |
| http://purl.uniprot.org/uniprot/#_Q5HYI3-mappedCitation-19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19553679 |
| http://purl.uniprot.org/uniprot/#_Q71U93-mappedCitation-19553679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19553679 |
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| http://purl.uniprot.org/uniprot/Q71U93 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19553679 |