| http://purl.uniprot.org/citations/19557502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19557502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19557502 | http://www.w3.org/2000/01/rdf-schema#comment | "RIOK3 was initially characterized as a homolog of Aspergillus nidulans sudD and showed down-regulation at the invasive front of malignant melanomas, but the molecular mechanism remains elusive. Here, we report that overexpression of RIOK3 inhibits TNFalpha-induced NF-kappaB activation, but down-regulation of endogenous RIOK3 expression by siRNA potentiates it. A yeast two-hybrid experiment revealed that RIOK3 interacted with caspase-10, and further, a GST pull-down assay and endogenous coimmunoprecipitation validated the interaction. We subsequently showed that the interaction was mediated by the RIO domain of RIOK3 and each death effector domain of caspase-10. Interestingly, our data demonstrated that RIOK3 suppressed caspase-10-mediated NF-kappaB activation by competing RIP1 and NIK to bind to caspase-10. Importantly, the kinase activity of RIOK3 was confirmed to be relevant to NF-kappaB signaling. Taken together, our findings strongly suggest that RIOK3 negatively regulates NF-kappaB signaling pathway activated by TNFalpha dependent on its kinase activity and NF-kappaB signaling pathway activated by caspase-10 independent of its kinase activity."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-009-0180-8"xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-009-0180-8"xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Huo K."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Huo K."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Shan J."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/author | "Shan J."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/name | "Mol. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/name | "Mol. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/pages | "113-120"xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/pages | "113-120"xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/title | "RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/19557502 | http://purl.uniprot.org/core/title | "RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway."xsd:string |