| http://purl.uniprot.org/citations/19559616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19559616 | http://www.w3.org/2000/01/rdf-schema#comment | "RASSF1A is a tumor suppressor gene that is inactivated by hypermethylation of its promoter region in most types of human cancers. The incidence of spontaneous or induced tumors is significantly higher in Rassf1a(-/-) mice than in wild-type mice, confirming the tumor suppressor function of RASSF1A. RASSF1A promotes apoptosis mainly through its interaction with the proapoptotic serine/threonine STE20-like kinases MST1 and 2. However, Rassf1a(-/-) mice do not show overt signs of deregulated apoptosis, suggesting that other RASSF1A effectors are also critical for tumor suppression. In a proteomics screen, we identified RAN GTPase, MST1 and 2 kinases, and alpha- and gamma-tubulin as RASSF1A-interacting proteins. We show that RASSF1A-induced microtubule hyperstability, a hallmark of RASSF1A expression, is RAN-GTP dependent. RASSF1A promotes the accumulation of the GTP-bound form of RAN via the MST2-induced phosphorylation of RCC1. Depletion of RASSF1A results in mislocalization of RCC1 to the mitotic spindle and spindle poles, leading to mitotic spindle abnormalities and prometaphase block. A similar mitotic delay is also observed with MST2 depletion. These findings reveal a mechanism for how RASSF1A controls microtubule stability and for how its loss compromises the integrity of the mitotic spindle, leading to aneuploidy and tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.05.064"xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "Kolch W."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "O'Neill E."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "Maher E.R."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "Matallanas D."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "Cooper W.N."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "Latif F."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "Dallol A."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/author | "Hesson L.B."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/pages | "1227-1232"xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/title | "RAN GTPase is a RASSF1A effector involved in controlling microtubule organization."xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19559616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19559616 |
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