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| http://purl.uniprot.org/citations/19561102 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently reported that heat shock protein 60 (HSP60) via TLR4 signaling activates B cells and induces them to proliferate and secrete IL-10. We now report that HSP60 inhibits mouse B cell apoptosis, spontaneous or induced by dexamethasone or anti-IgM activation. Unlike HSP60 enhancement of B cell proliferation and IL-10 secretion, TLR4 signaling was not required for the inhibition of apoptosis by HSP60; nevertheless, MyD88 was essential. Inhibition of apoptosis by HSP60 was associated with up-regulation of the antiapoptotic molecules Bcl-2, Bcl-x(L), and survivin, maintenance of the mitochondrial transmembrane potential, and inhibition of caspase-3 activation. Moreover, B cells incubated with HSP60 manifested prolonged survival following transfer into recipient mice. These results extend the varied role of HSP60 in the innate regulation of the adaptive immune response."xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0804238"xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/author | "Pevsner-Fischer M."xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/author | "Cohen I.R."xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/author | "Cohen-Sfady M."xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/author | "Margalit R."xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/pages | "890-896"xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/title | "Heat shock protein 60, via MyD88 innate signaling, protects B cells from apoptosis, spontaneous and induced."xsd:string |
| http://purl.uniprot.org/citations/19561102 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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