| http://purl.uniprot.org/citations/19561613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19561613 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell antigen receptors (TCRs) and B cell antigen receptors (BCRs) transmit low-grade signals necessary for the survival and maintenance of mature cell pools. We show here that TC21, a small GTPase encoded by Rras2, interacted constitutively with both kinds of receptors. Expression of a dominant negative TC21 mutant in T cells produced a rapid decrease in cell viability, and Rras2(-/-) mice were lymphopenic, possibly as a result of diminished homeostatic proliferation and impaired T cell and B cell survival. In contrast, TC21 was overexpressed in several human lymphoid malignancies. Finally, the p110delta catalytic subunit of phosphatidylinositol-3-OH kinase (PI(3)K) was recruited to the TCR and BCR in a TC21-dependent way. Consequently, we propose TC21 directly links antigen receptors to PI(3)K-mediated survival pathways."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1749"xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Merida I."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Martinez-Martin N."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Cubelos B."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Delgado P."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Bustelo X.R."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Bellas C."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Cipres A."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/author | "Calleja E."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/pages | "880-888"xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/title | "Essential function for the GTPase TC21 in homeostatic antigen receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/19561613 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19561613 |
| http://purl.uniprot.org/citations/19561613 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19561613 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRT5-mappedCitation-19561613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19561613 |
| http://purl.uniprot.org/uniprot/#_P62070-mappedCitation-19561613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19561613 |
| http://purl.uniprot.org/uniprot/#_P62071-mappedCitation-19561613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19561613 |
| http://purl.uniprot.org/uniprot/#_Q9CTF6-mappedCitation-19561613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19561613 |
| http://purl.uniprot.org/uniprot/Q9CTF6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19561613 |
| http://purl.uniprot.org/uniprot/P62070 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19561613 |