| http://purl.uniprot.org/citations/19561615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19561615 | http://www.w3.org/2000/01/rdf-schema#comment | "T helper type 2 (T(H)2) bias, which is the propensity of naive CD4(+) T cells to differentiate into interleukin 4 (IL-4)-secreting T(H)2 cells, is a genetic trait that affects susceptibility to infectious, autoimmune and allergic diseases. T(H)2 bias correlates with the amount of IL-4 initially secreted by newly activated helper T cells that feeds back positively through the pathway of the IL-4 receptor and the transcription factors STAT6 and GATA-3 to drive T(H)2 development. Here we identify Mina, a member of the jumonji C (JmjC) protein family, as a genetic determinant of T(H)2 bias. Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression. Our findings collectively provide mechanistic insight into an Il4-regulatory pathway that controls helper T cell differentiation and genetic variation in T(H)2 bias."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1747"xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Kitamura H."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Ohara O."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Okamoto M."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Chung L."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Koyanagi M."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Hijikata A."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Bix M."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/author | "Van Stry M."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/pages | "872-879"xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/title | "Mina, an Il4 repressor, controls T helper type 2 bias."xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/19561615 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19561615 |
| http://purl.uniprot.org/citations/19561615 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19561615 |
| http://purl.uniprot.org/uniprot/O88942#attribution-B39BFF8ABE7886C06C5AA5A87751E916 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19561615 |
| http://purl.uniprot.org/uniprot/Q8CD15#attribution-1FDEA32E7B0F0F6B4C9FC2324CF3CFF5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19561615 |
| http://purl.uniprot.org/uniprot/Q8CD15#attribution-633F986314B1BB7F5F72D4D44D87D83B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19561615 |
| http://purl.uniprot.org/uniprot/Q8CD15#attribution-B39BFF8ABE7886C06C5AA5A87751E916 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19561615 |