| http://purl.uniprot.org/citations/19563886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19563886 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila HOX transcription factor, Sex combs reduced (SCR), is required for determining labial and the first thoracic segmental identity. A Protein Phosphatase 2A holoenzyme assembled with the PP2A-B' regulatory subunit is proposed to specifically interact with, and dephosphorylate, the SCR homeodomain activating SCR protein activity. To test this hypothesis further, a null mutation was created in the PP2A-B' gene, PP2A-B'(Delta), using Flip-mediated, site-specific recombination. The number of sex comb bristles, salivary gland nuclei and pseudotracheal rows are SCR-dependent and were counted as a measure of SCR activity in vivo. Adults and larvae homozygous for PP2A-B'(Delta) showed no decrease in SCR activity. In addition, no evidence of functional redundancy of PP2A-B' with other regulatory subunits, Twins (TWS) and Widerborst (WDB), for dephosphorylation and activation of SCR activity was observed. In conclusion, a PP2A holoenzyme containing the PP2A-B' regulatory subunit has no role in the dephosphorylation and activation of SCR, and analysis of functional redundancy of PP2A regulatory subunits uncovered no evidence supporting a role of PP2A activity in dephosphorylation and activation of SCR."xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mod.2009.06.1084"xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/author | "Rosenfeld R."xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/author | "Percival-Smith A."xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/author | "Moazzen H."xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/pages | "605-610"xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/title | "Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B', for activation of Sex comb reduced activity in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/19563886 | http://purl.uniprot.org/core/volume | "126"xsd:string |
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