| http://purl.uniprot.org/citations/19570815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19570815 | http://www.w3.org/2000/01/rdf-schema#comment | "Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (P(combined) = 3.4 x 10(-9)). Notably, a second SNP (rs6718438) located approximately 450 bp away and in strong LD (r(2) = 0.77) with rs6717918 was previously found to be suggestive of a height association in 29 820 individuals of mainly northwestern European ancestry, and the over-expression of a nearby natriuretic peptide precursor type C (NPPC) gene, has been associated with overgrowth and skeletal anomalies. We also found a SNP (rs10472828) located on 5p14 near the natriuretic peptide receptor 3 (NPR3) gene, encoding a receptor of the NPPC ligand, to be associated with body height (P(combined) = 2.1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddp296"xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Krawczak M."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Schreiber S."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Hofman A."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "van Duijn C.M."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Estrada K."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Oostra B.A."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Vogelzangs N."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Rivadeneira F."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "von Eller-Eberstein H."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Uitterlinden A.G."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Aulchenko Y.S."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Boomsma D.I."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Hottenga J.J."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Penninx B.W."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Smit J.H."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Willemsen G."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "de Geus E.J."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "de Keijzer J."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Ohlsson C."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Lorentzon M."xsd:string |
| http://purl.uniprot.org/citations/19570815 | http://purl.uniprot.org/core/author | "Kayser M."xsd:string |