| http://purl.uniprot.org/citations/19570915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19570915 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress and inflammation are implicated in the pathogenesis of many age-related diseases. We have demonstrated previously that oxidative inactivation of the proteasome is a molecular link between oxidative stress and overexpression of interleukin (IL)-8. Here, we elucidated a novel signaling cascade that leads to up-regulation of IL-8 in response to proteasome inactivation. The sequence of events in this cascade includes proteasome inactivation, activation of mitogen-activated protein kinase kinase (MKK)3/MKK6, activation of p38 mitogen-activated protein kinase (MAPK), epidermal growth factor receptor phosphorylation, phosphatidylinositol 3-kinase (PI3K) activation and increased IL-8 expression. Blocking any of these signaling pathways abolished the up-regulation of IL-8 induced by proteasome inhibition. Although Akt is also activated in response to proteasome inactivation, we found that the PI3K-dependent up-regulation of IL-8 is independent of 3-phosphoinositide-dependent protein kinase (PDK)1 and Akt. Inhibition of PDK1 and Akt with chemical inhibitors or expression of constitutive active Akt had little effects on IL-8 expression in response to proteasome inactivation. In contrast, inhibition of interleukin 2-inducible T cell kinase, a kinase downstream of PI3K, significantly reduced the expression and secretion of IL-8 in response to proteasome inactivation. Together, these data elucidate a novel signaling network that leads to increased IL-8 production in response to proteasome inactivation."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-10-1068"xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/author | "Taylor A."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/author | "Thomas C.J."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/author | "Shang F."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/author | "Bian Q."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/author | "Pereira P."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/author | "Fernandes A.F."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/author | "Jiang J.K."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/pages | "3690-3699"xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/title | "Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/19570915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19570915 |
| http://purl.uniprot.org/citations/19570915 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19570915 |
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| http://purl.uniprot.org/uniprot/#_A0A510GDE6-mappedCitation-19570915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19570915 |
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| http://purl.uniprot.org/uniprot/#_B4E0K5-mappedCitation-19570915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19570915 |
| http://purl.uniprot.org/uniprot/#_B5TY33-mappedCitation-19570915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19570915 |
| http://purl.uniprot.org/uniprot/#_Q15454-mappedCitation-19570915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19570915 |
| http://purl.uniprot.org/uniprot/#_Q24M88-mappedCitation-19570915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19570915 |
| http://purl.uniprot.org/uniprot/#_L0R522-mappedCitation-19570915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19570915 |