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http://purl.uniprot.org/citations/19573021http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19573021http://www.w3.org/2000/01/rdf-schema#comment"Schizophrenia is a complex mental disorder with fairly high level of heritability. Dystrobrevin binding protein 1, a gene encoding dysbindin protein, is a susceptibility gene for schizophrenia that was identified by family-based association analysis. Recent studies revealed that dysbindin is involved in the exocytosis and/or formation of synaptic vesicles. However, the molecular function of dysbindin in synaptic transmission is largely unknown. To investigate the signaling pathway in which dysbindin is involved, we isolated dysbindin-interacting molecules from rat brain lysate by combining ammonium sulfate precipitation and dysbindin-affinity column chromatography, and identified dysbindin-interacting proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-tandem mass spectrometry. Proteins involved in protein localization process, including Munc18-1, were identified as dysbindin-interacting proteins. Munc18-1 was co-immunoprecipitated with dysbindin from rat brain lysate, and directly interacted with dysbindin in vitro. In primary cultured rat hippocampal neurons, a part of dysbindin was co-localized with Munc18-1 at pre-synaptic terminals. Our result suggests a role for dysbindin in synaptic vesicle exocytosis via interaction with Munc18-1."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.org/dc/terms/identifier"doi:10.1111/j.1471-4159.2009.06257.x"xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Kuroda K."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Kaibuchi K."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Shinoda T."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Ohta K."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Tsuboi D."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Hashimoto R."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Fujino Y."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Taya S."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Hikita T."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Taneichi-Kuroda S."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Funahashi Y."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/author"Uraguchi-Asaki J."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/name"J Neurochem"xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/pages"1567-1574"xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/title"Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein."xsd:string
http://purl.uniprot.org/citations/19573021http://purl.uniprot.org/core/volume"110"xsd:string
http://purl.uniprot.org/citations/19573021http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19573021
http://purl.uniprot.org/citations/19573021http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19573021
http://purl.uniprot.org/uniprot/#_P61765-mappedCitation-19573021http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19573021
http://purl.uniprot.org/uniprot/#_A6IZY7-mappedCitation-19573021http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19573021
http://purl.uniprot.org/uniprot/#_A6IZY8-mappedCitation-19573021http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19573021