| http://purl.uniprot.org/citations/19574343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19574343 | http://www.w3.org/2000/01/rdf-schema#comment | "Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddp302"xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Yeager M."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Ahn J."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Pfeiffer R."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Kraft P."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Chanock S.J."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Clavel-Chapelon F."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Hunter D.J."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Trichopoulos D."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Berndt S.I."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Hayes R.B."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Schumacher F.R."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Giovannucci E."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Boeing H."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Stattin P."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Hoover R.N."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Albanes D."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Andriole G.L."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Feigelson H.S."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Thun M.J."xsd:string |
| http://purl.uniprot.org/citations/19574343 | http://purl.uniprot.org/core/author | "Virtamo J."xsd:string |