| http://purl.uniprot.org/citations/19575011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19575011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19575011 | http://www.w3.org/2000/01/rdf-schema#comment | "Post-translational histone modifications have essential roles in controlling nuclear processes; however, the specific mechanisms regulating these modifications and their combinatorial activities remain elusive. Cyclin-dependent kinase 9 (CDK9) regulates gene expression by phosphorylating transcriptional regulatory proteins, including the RNA polymerase II carboxy-terminal domain. Here, we show that CDK9 activity is essential for maintaining global and gene-associated levels of histone H2B monoubiquitination (H2Bub1). Furthermore, CDK9 activity and H2Bub1 help to maintain correct replication-dependent histone messenger RNA (mRNA) 3'-end processing. CDK9 knockdown consistently resulted in inefficient recognition of the correct mRNA 3'-end cleavage site and led to increased read-through of RNA polymerase II to an alternative downstream polyadenylation signal. Thus, CDK9 acts to integrate phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.108"xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.108"xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Schreiber L."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Schreiber L."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Oren M."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Oren M."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Shema E."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Shema E."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Eick D."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Eick D."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Aylon Y."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Aylon Y."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Chapman R.D."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Chapman R.D."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Johnsen S.A."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Johnsen S.A."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Minsky N."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Minsky N."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Pirngruber J."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Pirngruber J."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Shchebet A."xsd:string |
| http://purl.uniprot.org/citations/19575011 | http://purl.uniprot.org/core/author | "Shchebet A."xsd:string |