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http://purl.uniprot.org/citations/19578685http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19578685http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder.

Method

The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls.

Results

There were no differences in genotypic distributions between patients and controls (chi2 = 0.98; 2 d.f.; p = 0.61).

Discussion

Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied.

Conclusion

The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.org/dc/terms/identifier"doi:10.1590/s1516-44462009000200009"xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Pereira C.A."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Miguel E.C."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Palacios S.A."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Shavitt R.G."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Cordeiro Q."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Guilherme L."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Hounie A.G."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Cappi C."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/author"Sampaio A.S."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/name"Braz J Psychiatry"xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/pages"131-135"xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/title"Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder."xsd:string
http://purl.uniprot.org/citations/19578685http://purl.uniprot.org/core/volume"31"xsd:string
http://purl.uniprot.org/citations/19578685http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19578685
http://purl.uniprot.org/citations/19578685http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19578685
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http://purl.uniprot.org/uniprot/#_A0A1U9X847-mappedCitation-19578685http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19578685
http://purl.uniprot.org/uniprot/#_A0A286SD72-mappedCitation-19578685http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19578685
http://purl.uniprot.org/uniprot/#_A0A286SD75-mappedCitation-19578685http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19578685
http://purl.uniprot.org/uniprot/#_A0A286SD76-mappedCitation-19578685http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19578685
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