Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/19580679http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19580679http://www.w3.org/2000/01/rdf-schema#comment"

Background

Neuropilin-2 (Nrp2) is a receptor for vascular endothelial growth factor-C (VEGF-C), which is a well-known lymphangiogenic factor and plays an important role in lymph node metastasis of various human cancers, including breast cancer. Recently, Nrp2 was shown to play a role in cancer by promoting tumor cell metastasis. CXC chemokine receptor 4 (CXCR4) also promotes tumor metastasis. In the previous studies, we demonstrated that VEGF-C and cytoplasmic CXCR4 expressions were correlated with poorer patient prognosis (BMC Cancer 2008,8:340; Breast Cancer Res Treat 2005, 91:125-132).

Methods

The relationship between Nrp2 expression and lymph node metastasis, VEGF-C expression, CXCR4 expression, and other established clinicopathological variables (these data were cited in our previous papers), including prognosis, was analyzed in human breast cancer. Effects of neutralizing anti-Nrp2 antibody on CXCR4 expression and chemotaxis were assessed in MDA-MB-231 breast cancer cells.

Results

Nrp2 expression was observed in 53.1% (60 of 113) of the invasive breast carcinomas. Nrp2 expression was significantly correlated with lymph node metastasis, VEGF-C expression, and cytoplasmic CXCR4 expression. Survival curves determined by the Kaplan-Meier method showed that Nrp2 expression was associated with reduced overall survival. In multivariate analysis, Nrp2 expression emerged as a significant independent predictor for overall survival. Neutralizing anti-Nrp2 antibody blocks cytoplasmic CXCR4 expression and CXCR4-induced migration in MDA-MB-231 cells.

Conclusion

Nrp2 expression was correlated with lymph node metastasis, VEGF-C expression, and cytoplasmic CXCR4 expression. Nrp2 expression may serve as a significant prognostic factor for long-term survival in breast cancer. Our data also showed a role for Nrp2 in regulating cytoplasmic CXCR4 expression in vitro."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.org/dc/terms/identifier"doi:10.1186/1471-2407-9-220"xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Nakamura Y."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Inagaki M."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Nakahara M."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Tsujimoto M."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Akamatsu H."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Sanke T."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Yasuoka H."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Kodama R."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/author"Yoshidome K."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/name"BMC Cancer"xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/pages"220"xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/title"Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression."xsd:string
http://purl.uniprot.org/citations/19580679http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/19580679http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19580679
http://purl.uniprot.org/citations/19580679http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19580679
http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-19580679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19580679
http://purl.uniprot.org/uniprot/#_A0A0U3GXA9-mappedCitation-19580679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19580679
http://purl.uniprot.org/uniprot/#_A0A8Q3WLL1-mappedCitation-19580679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19580679
http://purl.uniprot.org/uniprot/#_A8K4G9-mappedCitation-19580679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19580679
http://purl.uniprot.org/uniprot/#_B7ZL68-mappedCitation-19580679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19580679
http://purl.uniprot.org/uniprot/#_O60462-mappedCitation-19580679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19580679
▶