| http://purl.uniprot.org/citations/19580783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19580783 | http://www.w3.org/2000/01/rdf-schema#comment | "TTRAP is a PML-NB protein that is involved in the NF-kappaB signaling pathway. TTRAP was recently identified by yeast two-hybrid analysis as a HIV-1 integrase (HIV-1 IN) interacting protein. This interaction was verified by co-immunoprecipitation, GST pull-down, and intracellular imaging, and deletion assays suggested that the N-terminal 180 residues of TTRAP are responsible for the interaction. In stable TTRAP knock-down cell lines, the integration of viral vectors decreased significantly compared with non-silenced cell lines. Conversely, overexpression of TTRAP by transient transfection increased the percentage of integration events. This is the first time that TTRAP has been shown to interact with HIV-1 IN and facilitate lentiviral vector integration. These findings reveal a new function of TTRAP and expand our understanding of the cellular response to HIV infection. The interaction between TTRAP and HIV-1 IN may be useful in designing new anti-viral strategies as well as for improving the efficiency of lentiviral-vector-mediated gene delivery."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.06.153"xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Jia W."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Wang J.J."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Tian L."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Zhang J.Q."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Li W.J."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Chen J.Z."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/author | "Xue J.L."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/pages | "256-260"xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/title | "Cellular protein TTRAP interacts with HIV-1 integrase to facilitate viral integration."xsd:string |
| http://purl.uniprot.org/citations/19580783 | http://purl.uniprot.org/core/volume | "387"xsd:string |
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