| http://purl.uniprot.org/citations/19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19582739 | http://www.w3.org/2000/01/rdf-schema#comment | "The glycosphingolipid sulfatide (SO(3)-3Galbeta1Cer) is a demonstrated ligand for a subset of CD1d-restricted NKT cells, which could regulate experimental autoimmune encephalomyelitis, a murine model for multiple sclerosis, as well as tumor immunity and experimental hepatitis. Native sulfatide is a mixture of sulfatide isoforms, i.e. sulfatide molecules with different long-chain bases and fatty acid chain lengths and saturation. Here, we demonstrate that sulfatide-specific CD1d-restricted murine NKT hybridomas recognized several different sulfatide isoforms. These included the physiologically relevant isoforms C24:1 and C24:0, major constituents of the myelin sheet of the nervous system, and C16:0, prominent in the pancreatic islet beta-cells. The most potent sulfatide isoform was lysosulfatide (lacking a fatty acid). Shortened fatty acid chain length (C24:1 versus C18:1), or saturation of the long fatty acid (C24:0), resulted in reduced stimulatory capacity, and fatty acid hydroxylation abolished the response. Moreover, sulfatide was not responsible for the natural autoreactivity toward splenocytes by XV19 T hybridoma cells. Our results reveal a promiscuity in the recognition of sulfatide isoforms by a CD1d-restricted NKT-cell clone, and suggest that sulfatide, a major component of the myelin sheet and pancreatic beta-cells, is one of several natural ligands for type II CD1d-restricted NKT cells."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200839001"xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Teneberg S."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Mansson J.E."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Blomqvist M."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Brigl M."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Cardell S.L."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Lofbom L."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Osterbye T."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/author | "Rhost S."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/pages | "1726-1735"xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/title | "Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells."xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/19582739 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19582739 |
| http://purl.uniprot.org/citations/19582739 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19582739 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J090-mappedCitation-19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19582739 |
| http://purl.uniprot.org/uniprot/#_B9VQY2-mappedCitation-19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19582739 |
| http://purl.uniprot.org/uniprot/#_E9Q395-mappedCitation-19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19582739 |
| http://purl.uniprot.org/uniprot/#_P11609-mappedCitation-19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19582739 |
| http://purl.uniprot.org/uniprot/#_P11610-mappedCitation-19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19582739 |
| http://purl.uniprot.org/uniprot/#_Q7TMK5-mappedCitation-19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19582739 |
| http://purl.uniprot.org/uniprot/#_Q6PG97-mappedCitation-19582739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19582739 |