| http://purl.uniprot.org/citations/19584075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19584075 | http://www.w3.org/2000/01/rdf-schema#comment | "This study was aimed to identify novel susceptibility variants for second primary tumor (SPT) or recurrence in curatively treated early-stage head and neck squamous cell carcinoma (HNSCC) patients. We constructed a custom chip containing a comprehensive panel of 9,645 chromosomal and mitochondrial single nucleotide polymorphisms (SNP) representing 998 cancer-related genes selected by a systematic prioritization schema. Using this chip, we genotyped 150 early-stage HNSCC patients with and 300 matched patients without SPT/recurrence from a prospectively conducted randomized trial and assessed the association of these SNPs with risk of SPT/recurrence. Individually, six chromosomal SNPs and seven mitochondrial SNPs were significantly associated with risk of SPT/recurrence after adjustment for multiple comparisons. A strong gene-dosage effect was observed when these SNPs were combined, as evidenced by a progressively increasing SPT/recurrence risk as the number of unfavorable genotypes increased (P for trend < 1.00 x 10(-20)). Several polygenic analyses suggest an important role of interconnected functional network and gene-gene interaction in modulating SPT/recurrence. Furthermore, incorporation of these genetic markers into a multivariate model improved significantly the discriminatory ability over the models containing only clinical and epidemiologic variables. This is the first large-scale systematic evaluation of germ-line genetic variants for their roles in HNSCC SPT/recurrence. The study identified several promising susceptibility loci and showed the cumulative effect of multiple risk loci in HNSCC SPT/recurrence. Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.org/dc/terms/identifier | "doi:10.1158/1940-6207.capr-09-0025"xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Lee J.J."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Spitz M.R."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Lotan R."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Khuri F.R."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Hong W.K."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/author | "Lippman S.M."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/name | "Cancer Prev Res (Phila)"xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/pages | "617-624"xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/title | "Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants."xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/19584075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19584075 |
| http://purl.uniprot.org/citations/19584075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19584075 |
| http://purl.uniprot.org/uniprot/#_A0A0F6TMZ9-mappedCitation-19584075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584075 |
| http://purl.uniprot.org/uniprot/#_A0A0F6TN25-mappedCitation-19584075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584075 |
| http://purl.uniprot.org/uniprot/#_A0A0F6TN92-mappedCitation-19584075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584075 |
| http://purl.uniprot.org/uniprot/#_A0A068BDS2-mappedCitation-19584075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584075 |