| http://purl.uniprot.org/citations/19584291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19584291 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic proteins (BMP) have been shown to affect tumorigenesis in a variety of tumors. Quantitative PCR analysis revealed down-regulation of BMP2 and BMP5 in tissue samples from adrenocortical carcinoma and adrenocortical tumor cell lines compared with normal adrenal glands. Integrity of BMP-dependent pathways in these cell lines could be shown by activation of the Smad1/5/8 pathway with subsequent increase of ID protein expression upon incubation with BMP2 or BMP5. On a functional level, BMP treatment resulted in inhibition of cell proliferation and viability in a dose- and time-dependent manner. This growth inhibitory effect was associated with BMP-dependent reduction of AKT phosphorylation under baseline conditions and under insulin-like growth factor costimulation. Furthermore, steroidogenic function, including melanocortin-2 receptor and steroidogenic enzyme expressions, was profoundly reduced. In vitro demethylation treatment and overexpression of GATA6 resulted in reactivation of BMP-dependent pathways with concomitant modulation of steroidogenesis. Taken together, we show that loss of expression of members of the BMP family of ligands is a common finding in adrenocortical tumors and we provide evidence that BMP-dependent pathways are likely to be involved in the modulation of the malignant and functional phenotype of adrenocortical cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-08-4428"xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/author | "Kappler R."xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/author | "Beuschlein F."xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/author | "Auernhammer C.J."xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/author | "Johnsen I.K."xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/pages | "5784-5792"xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/title | "Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis."xsd:string |
| http://purl.uniprot.org/citations/19584291 | http://purl.uniprot.org/core/volume | "69"xsd:string |
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