| http://purl.uniprot.org/citations/19584403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19584403 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute myelogenous leukemia is driven by leukemic stem cells (LSCs) generated by mutations that confer (or maintain) self-renewal potential coupled to an aberrant differentiation program. Using retroviral mutagenesis, we identified genes that generate LSCs in collaboration with genetic disruption of the gene encoding interferon response factor 8 (Irf8), which induces a myeloproliferation in vivo. Among the targeted genes, we identified Mef2c, encoding a MCM1-agamous-deficiens-serum response factor transcription factor, and confirmed that overexpression induced a myelomonocytic leukemia in cooperation with Irf8 deficiency. Strikingly, several of the genes identified in our screen have been reported to be up-regulated in the mixed-lineage leukemia (MLL) subtype. High MEF2C expression levels were confirmed in acute myelogenous leukemia patient samples with MLL gene disruptions, prompting an investigation of the causal interplay. Using a conditional mouse strain, we demonstrated that Mef2c deficiency does not impair the establishment or maintenance of LSCs generated in vitro by MLL/ENL fusion proteins; however, its loss led to compromised homing and invasiveness of the tumor cells. Mef2c-dependent targets included several genes encoding matrix metalloproteinases and chemokine ligands and receptors, providing a mechanistic link to increased homing and motility. Thus, MEF2C up-regulation may be responsible for the aggressive nature of this leukemia subtype."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-05-158196"xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Slany R.K."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Engelmann A."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Stocking C."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Delwel R."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Arnold M.A."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Schwieger M."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Schuler A."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Forster M."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Valk P.J."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/author | "Lohler J."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/pages | "2476-2488"xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/title | "Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C."xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/19584403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19584403 |
| http://purl.uniprot.org/citations/19584403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19584403 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDK0-mappedCitation-19584403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584403 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDQ1-mappedCitation-19584403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584403 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDT0-mappedCitation-19584403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584403 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE18-mappedCitation-19584403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19584403 |