| http://purl.uniprot.org/citations/19586661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19586661 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian target of rapamycin (mTOR) is an evolutionarily conserved kinase which plays a role in integrating environmental cues. mTOR signals via two complexes: TORC1, which contains the Regulatory Associated Protein of TOR (raptor), and TORC2, which contains the Rapamycin-insensitive Companion of TOR (rictor). The immunosuppressive/anti-cancer agent rapamycin inhibits TORC1 function by disrupting the mTOR-raptor interaction. In an effort to understand the downstream consequences of TORC1 activation in T cells we performed a proteomic analysis of raptor binding proteins. Using this approach we have identified Hsp90 as an activation-induced binding partner of raptor in T cells. Pharmacologic inhibition of Hsp90 leads to a decrease in raptor expression and TORC1 activity. Furthermore, full T cell activation during Hsp90 blockade leads to T cell tolerance in the form of anergy. Overall, our findings suggest that Hsp90 inhibitors might represent a novel means of promoting T cell tolerance."xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2009.05.185"xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/author | "Cotter R.J."xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/author | "Delgoffe G.M."xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/author | "Powell J.D."xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/author | "Kole T.P."xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/pages | "2694-2698"xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/title | "Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation."xsd:string |
| http://purl.uniprot.org/citations/19586661 | http://purl.uniprot.org/core/volume | "46"xsd:string |
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