| http://purl.uniprot.org/citations/19590012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19590012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19590012 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form of the cytokine-like molecule Spätzle. During the immune response, Spätzle is processed by complex cascades of serine proteases, which are activated by secreted pattern-recognition receptors. Here, we demonstrate the essential role of ModSP, a modular serine protease, in the activation of the Toll pathway by gram-positive bacteria and fungi. Our analysis shows that ModSP integrates signals originating from the circulating recognition molecules GNBP3 and PGRP-SA and connects them to the Grass-SPE-Spätzle extracellular pathway upstream of the Toll receptor. It also reveals the conserved role of modular serine proteases in the activation of insect immune reactions."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901924106"xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901924106"xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Lemaitre B."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Lemaitre B."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Lee B.L."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Lee B.L."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Buchon N."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Buchon N."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Guillou A."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Guillou A."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Kwon H.M."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Kwon H.M."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Poidevin M."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Poidevin M."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Sottas V."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/author | "Sottas V."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/pages | "12442-12447"xsd:string |
| http://purl.uniprot.org/citations/19590012 | http://purl.uniprot.org/core/pages | "12442-12447"xsd:string |