| http://purl.uniprot.org/citations/19590578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19590578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19590578 | http://www.w3.org/2000/01/rdf-schema#comment | "Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA-dependent activator of IRFs/Z-DNA binding protein 1) was identified as a cytoplasmic DNA sensor and shown to activate the interferon regulatory factor (IRF) and nuclear factor-kappa B (NF-kappaB) transcription factors, leading to type-I interferon production. DAI-induced IRF activation depends on TANK-binding kinase 1 (TBK1), whereas signalling pathways and molecular components involved in NF-kappaB activation remain elusive. Here, we report the identification of two receptor-interacting protein (RIP) homotypic interaction motifs (RHIMs) in the DAI protein sequence, and show that these domains relay DAI-induced NF-kappaB signals through the recruitment of the RHIM-containing kinases RIP1 and RIP3. We show that knockdown of not only RIP1, but also RIP3 affects DAI-induced NF-kappaB activation. Importantly, RIP recruitment to DAI is inhibited by the RHIM-containing murine cytomegalovirus (MCMV) protein M45. These findings delineate the DAI signalling pathway to NF-kappaB and suggest a possible new immune modulation strategy of the MCMV."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.109"xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.109"xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Schroder K."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Schroder K."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Benedict C.A."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Benedict C.A."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Vazquez J."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Vazquez J."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Meylan E."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Meylan E."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Rebsamen M."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Rebsamen M."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Heinz L.X."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Heinz L.X."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Michallet M.C."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/author | "Michallet M.C."xsd:string |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19590578 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |