| http://purl.uniprot.org/citations/19593744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19593744 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied the effects of the presence of the HLA-DR15 allele on the experimental and clinical features of myelodysplastic syndrome (MDS) by assessing the clinical data of 136 patients with MDS. We observed that the frequency of HLA-DR15 expression in MDS patients (38.7%) was significantly higher than that in the healthy controls (p < 0.01). We noted the following observations with regard to disease progression: None of the 46 HLA-DR15 positive patients with international prognostic scoring system (IPSS) scores or=1.5 and the presence of >or=5% blasts in the bone marrow in the DR15-positive patients were lower than the corresponding findings in the DR15-negative patients. In addition, we also recorded the following observations with regard to bone marrow (BM) failure: The bicytopenia/pancytopenia ratio in the DR15-positive patients was higher than that in the DR15-negative patients (92.4 vs. 78.3%; p = 0.029). The peripheral-neutrophil count and the platelet count in the DR15-positive patients were lower than those in the DR15-negative patients (p = 0.028 and p = 0.011, respectively). Moreover, hypocellularity was more easily detectable in the DR15-positive patients (26.4 vs. 16.9%). In addition, the BM CD4+ lymphocyte count and the CD4/CD8 ratio in the DR15-positive patients were higher than the corresponding values in the DR15-negative patients (p < 0.05 for both). However, there were no significant differences between the polarization of T-helper (T(h)) and T-cytotoxic (T(c)) cells and the cytokine levels in these two patient groups. We concluded that the presence of the HLA-DR15 allele is indicative of a genetic susceptibility to MDS and, the presence of the HLA-DR15 allele showed less association with disease progression and greater association with BM failure."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.org/dc/terms/identifier | "doi:10.1002/hon.907"xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Xiao L."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Yan Z."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Ying T."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Quan P."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Luxi S."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Qiong L."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/author | "Yizhi L."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/name | "Hematol Oncol"xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/pages | "98-103"xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/title | "Experimental and clinical characteristics in myelodysplastic syndrome patients with or without HLA-DR15 allele."xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/19593744 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19593744 |
| http://purl.uniprot.org/citations/19593744 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19593744 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19593744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19593744 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19593744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19593744 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19593744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19593744 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-19593744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19593744 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-19593744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19593744 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-19593744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19593744 |