| http://purl.uniprot.org/citations/19596235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19596235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19596235 | http://www.w3.org/2000/01/rdf-schema#comment | "Structure-specific endonucleases mediate cleavage of DNA structures formed during repair of collapsed replication forks and double-strand breaks (DSBs). Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. Depletion of SLX4 causes sensitivity to mitomycin C and camptothecin and reduces the efficiency of DSB repair in vivo. SLX4 complexes cleave 3' flap, 5' flap, and replication fork structures; yet unlike other endonucleases associated with SLX4, the SLX1-SLX4 module promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), identifying SLX1-SLX4 as a HJ resolvase. Thus, SLX4 assembles a modular toolkit for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.06.030"xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.06.030"xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Sowa M.E."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Sowa M.E."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Smogorzewska A."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Smogorzewska A."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "O'Connell B.C."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "O'Connell B.C."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Svendsen J.M."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/author | "Svendsen J.M."xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/pages | "63-77"xsd:string |
| http://purl.uniprot.org/citations/19596235 | http://purl.uniprot.org/core/pages | "63-77"xsd:string |