| http://purl.uniprot.org/citations/19596317 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19596317 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt/beta-catenin signaling is highly active in the dorsal retinal pigment epithelium (RPE) during eye development. To study the role of Wnt/beta-catenin signaling in the RPE development we used a conditional Cre/loxP system in mice to inactivate or ectopically activate Wnt/beta-catenin signaling in the RPE. Inactivation of Wnt/beta-catenin signaling results in transdifferentiation of RPE to neural retina (NR) as documented by downregulation of RPE-specific markers Mitf and Otx2 and ectopic expression of NR-specific markers Chx10 and Rx, respectively. In contrast, ectopic activation of Wnt/beta-catenin signaling results in the disruption of the RPE patterning, indicating that precise spatial and temporal regulation of Wnt/beta-catenin signaling is required for normal RPE development. Using chromatin immunoprecipitation (ChIP) and reporter gene assays we provide evidence that Otx2 and RPE-specific isoform of Mitf, Mitf-H, are direct transcriptional targets of Wnt/beta-catenin signaling. Combined, our data suggest that Wnt/beta-catenin signaling plays an essential role in development of RPE by maintaining or inducing expression of Mitf and Otx2."xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2009.07.002"xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/author | "Kozmik Z."xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/author | "Korinek V."xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/author | "Fujimura N."xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/pages | "31-45"xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/title | "Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium."xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://purl.uniprot.org/core/volume | "334"xsd:string |
| http://purl.uniprot.org/citations/19596317 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19596317 |
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| http://purl.uniprot.org/uniprot/#_D3Z581-mappedCitation-19596317 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19596317 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-19596317 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19596317 |
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