| http://purl.uniprot.org/citations/19596989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19596989 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite being a proinflammatory cytokine, TNF-alpha preconditions neurons against various toxic insults. However, underlying molecular mechanisms are poorly understood. The present study identifies the importance of CREB-binding protein (CBP) in facilitating TNF-alpha-mediated preconditioning in neurons. Treatment of rat primary neurons with fibrillar amyloid beta1-42 (Abeta) resulted in the loss of CBP protein. However, this loss was compensated by TNF-alpha preconditioning as the expression of neuronal CBP was up-regulated in response to TNF-alpha treatment. The induction of CBP by TNF-alpha was observed only in neurons, but not in astroglia and microglia, and it was contingent on the activation of transcription factor NF-kappaB. Interestingly, antisense knockdown of CBP abrogated the TNF-alpha-mediated preconditioning of neurons against Abeta and glutamate toxicity. Similarly in vivo, preadministration of TNF-alpha in mouse neocortex prevented Abeta-induced apoptosis and loss of choline acetyltransferase-positive cholinergic neurons. However, coadministration of cbp antisense, but not scrambled oligonucleotides, negated the protective effect of TNF-alpha against Abeta neurotoxicity. This study illustrates a novel biological role of TNF-alpha in increasing neuron-specific expression of CBP for preconditioning that may have therapeutic potential against neurodegenerative disorders."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0801892"xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/author | "Ghosh A."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/author | "Dudek S.M."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/author | "Fung Y.K."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/author | "Saha R.N."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/author | "Pahan K."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/author | "Palencia C.A."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/pages | "2068-2078"xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/title | "TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein."xsd:string |
| http://purl.uniprot.org/citations/19596989 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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