| http://purl.uniprot.org/citations/19597184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19597184 | http://www.w3.org/2000/01/rdf-schema#comment | "BCL2 and MYC are oncogenes commonly deregulated in lymphomas. Concurrent BCL2 and MYC translocations (BCL2(+)/MYC(+)) were identified in 54 samples by karyotype and/or fluorescence in situ hybridization with the aim of correlating clinical and cytogenetic characteristics to overall survival. BCL2(+)/MYC(+) lymphomas were diagnosed as B-cell lymphoma unclassifiable (BCLU; n = 36) with features intermediate between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL); DLBCL (n = 17), or follicular lymphoma (n = 1). Despite the presence of a t(14;18), 5 cases were BCL2 protein-negative. Nonimmunoglobulin gene/MYC (non-IG/MYC) translocations occurred in 24 of 54 cases (44%) and were highly associated with DLBCL morphology (P < .001). Over a median follow-up of 5.3 years, 6 patients remained in remission and 32 died within 6 months of the MYC(+) rearrangement, irrespective of whether MYC(+) occurred at diagnosis (31 of 54) or transformation (23 of 54; P = .53). A non-IG/MYC translocation partner, absent BCL2 protein expression and treatment with rituximab-based chemotherapy, were associated with a more favorable outcome, but a low International Prognostic Index score and DLBCL morphology were independent predictors of overall survival. A comprehensive cytogenetic analysis of BCL2 and MYC status on all aggressive lymphomas may identify a group of high-risk patients who may benefit from chemotherapeutic regimens that include rituximab and/or BCL2-targeted therapy."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-03-212191"xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Siebert R."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Woods R."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Kuruvilla J."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Dyer M.J."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Gascoyne R.D."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Steidl C."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Connors J.M."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Horsman D.E."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Johnson N.A."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Ludkovski O."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Ben-Neriah S."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Savage K.J."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/author | "Klasa R."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/pages | "2273-2279"xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/title | "Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival."xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/19597184 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19597184 |
| http://purl.uniprot.org/citations/19597184 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19597184 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-19597184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19597184 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ4-mappedCitation-19597184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19597184 |