| http://purl.uniprot.org/citations/19597337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19597337 | http://www.w3.org/2000/01/rdf-schema#comment | "Before anaphase, kinetochores of sister chromatid (SC) pairs must be attached to microtubules emanating from opposing spindle poles. The conserved Aurora B kinase Ipl1 and its adaptor INCENP/Sli15 correct defective attachments and promote SC bi-orientation. Ame1 and Okp1 are essential components of the COMA sub-complex of the budding yeast central kinetochore, and Ame1 has been demonstrated to physically interact with Sli15. Here, we examine the significance of the Ame1-Sli15 interaction in vivo. We find Sli15 localization at kinetochores is reduced in the absence of Ame1. We demonstrate a role for Ame1 in the correction of defective attachments. While overexpression of OKP1 restores kinetochore localization of the mutant Ame1-4 protein, Sli15 localization is not restored and defective attachments are not corrected. Our findings reveal a new role for the central kinetochore in promoting Sli15 function, and suggest functional Ame1 is required for the correction of defective attachments by promoting the localization of Sli15/INCENP at kinetochores."xsd:string |
| http://purl.uniprot.org/citations/19597337 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.8.16.9267"xsd:string |
| http://purl.uniprot.org/citations/19597337 | http://purl.uniprot.org/core/author | "Vogel J."xsd:string |
| http://purl.uniprot.org/citations/19597337 | http://purl.uniprot.org/core/author | "Knockleby J."xsd:string |
| http://purl.uniprot.org/citations/19597337 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19597337 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/19597337 | http://purl.uniprot.org/core/pages | "2570-2577"xsd:string |
| http://purl.uniprot.org/citations/19597337 | http://purl.uniprot.org/core/title | "The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments."xsd:string |
| http://purl.uniprot.org/citations/19597337 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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| http://purl.uniprot.org/uniprot/P38313#attribution-B7B0217D80ADB24EECE7E4844FB5BADA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19597337 |
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| http://purl.uniprot.org/uniprot/#_P53298-mappedCitation-19597337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19597337 |
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