| http://purl.uniprot.org/citations/19597844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19597844 | http://www.w3.org/2000/01/rdf-schema#comment | "To confirm and refine associations of human leukocyte antigen (HLA) genotypes with variable antibody (Ab) responses to hepatitis B vaccination, we have analyzed 255 HIV-1 seropositive (HIV(+)) youth and 80 HIV-1 seronegatives (HIV(-)) enrolled into prospective studies. In univariate analyses that focused on HLA-DRB1, -DQA1, and -DQB1 alleles and haplotypes, the DRB1*03 allele group and DRB1*0701 were negatively associated with the responder phenotype (serum Ab concentration > or = 10 mIU/mL) (P = 0.026 and 0.043, respectively). Collectively, DRB1*03 and DRB1*0701 were found in 42 (53.8%) out of 78 non-responders (serum Ab <10 mIU/mL), 65 (40.6%) out of 160 medium responders (serum Ab 10-1,000 mIU/mL), and 27 (27.8%) out of 97 high responders (serum Ab >1,000 mIU/mL) (P < 0.001 for trend). Meanwhile, DRB1*08 was positively associated with the responder phenotype (P = 0.010), mostly due to DRB1*0804 (P = 0.008). These immunogenetic relationships were all independent of non-genetic factors, including HIV-1 infection status and immunodeficiency. Alternative analyses confined to HIV(+) youth or Hispanic youth led to similar findings. In contrast, analyses of more than 80 non-coding, single nucleotide polymorphisms within and beyond the three HLA class II genes revealed no clear associations. Overall, several HLA-DRB1 alleles were major predictors of differential Ab responses to hepatitis B vaccination in youth, suggesting that T-helper cell-dependent pathways mediated through HLA class II antigen presentation are critical to effective immune response to recombinant vaccines."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00439-009-0720-z"xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Ahmad S."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Wilson C.M."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Shrestha S."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Shao W."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Ni R."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Cunningham C.K."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Kapogiannis B.G."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/author | "Flynn P.M."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/name | "Hum Genet"xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/pages | "685-696"xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/title | "Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth."xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/19597844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19597844 |
| http://purl.uniprot.org/citations/19597844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19597844 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19597844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19597844 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19597844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19597844 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19597844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19597844 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-19597844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19597844 |