| http://purl.uniprot.org/citations/19597959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19597959 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans pretreatment with juglone, a generator of reactive oxygen species (ROS) provides a subsequently increased ROS-resistance. We investigated whether juglone at low or high concentrations when provided via the oral route in a liquid axenic medium affects normal lifespan of C. elegans. High juglone concentrations led to premature death, low concentrations were tolerated well and caused a prolongation of lifespan. Lifespan extension under moderate oxidative stress was associated with increased expression of small heat-shock protein HSP-16.2, enhanced glutathione levels, and nuclear translocation of DAF-16. Silencing or deletion of DAF-16 prevented the juglone-induced adaptations. RNA-interference for SIR-2.1 had the same effects as the deletion of DAF-16 but did not affect nuclear accumulation of DAF-16. Our studies demonstrate that DAF-16- and SIR-2.1-dependent alterations in gene expression after a ROS challenge lead to a lifespan extension in C. elegans as long as the stressor concentration does not exceed the saturable protective capacity."xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10522-009-9239-x"xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/author | "Daniel H."xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/author | "Wenzel U."xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/author | "Hartwig K."xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/author | "Heidler T."xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/name | "Biogerontology"xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/pages | "183-195"xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1."xsd:string |
| http://purl.uniprot.org/citations/19597959 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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