| http://purl.uniprot.org/citations/19603141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19603141 | http://www.w3.org/2000/01/rdf-schema#comment | "A costimulatory signal from an inducible costimulator (ICOS) of T cells plays a critical role in immunological homeostasis. This study shows that the interaction of ICOSIg and its ligand (ICOSL) on mouse bone marrow-derived dendritic cells (DCs) induces a p38-MAPK dependent elevation of interleukin 6 (IL-6). It also enhances phagocytosis and the antigen-presentation function of DCs in vitro, further favoring cell-mediated immunity in vivo. As seen for other types of costimulator molecules expressed in the T cells in the CD28 family, it is shown here for the first time that ICOS can also deliver reverse signals through its ligand to ICOSL-expressing cells. These reverse signals in turn transfer positive immunogenic information to bone marrow-derived DCs. Our work therefore provides new recognition of an ICOSL/ICOS signal pathway in immunity and also supplies more evidence that this ICOSL/ICOS signal pathway is a reasonable target for therapeutic drugs."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-009-0090-7"xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Shen Q."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Tang G."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Ding Q."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/author | "Qin Q."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/pages | "3067-3080"xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/title | "Reverse signaling using an inducible costimulator to enhance immunogenic function of dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/19603141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19603141 |
| http://purl.uniprot.org/citations/19603141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19603141 |
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