| http://purl.uniprot.org/citations/19608861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19608861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19608861 | http://www.w3.org/2000/01/rdf-schema#comment | "Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles. We used high-resolution mass spectrometry to identify 3600 lysine acetylation sites on 1750 proteins and quantified acetylation changes in response to the deacetylase inhibitors suberoylanilide hydroxamic acid and MS-275. Lysine acetylation preferentially targets large macromolecular complexes involved in diverse cellular processes, such as chromatin remodeling, cell cycle, splicing, nuclear transport, and actin nucleation. Acetylation impaired phosphorylation-dependent interactions of 14-3-3 and regulated the yeast cyclin-dependent kinase Cdc28. Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1175371"xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1175371"xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Gnad F."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Gnad F."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Kumar C."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Kumar C."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Nielsen M.L."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Nielsen M.L."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Olsen J.V."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Olsen J.V."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Rehman M."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Rehman M."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Walther T.C."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/author | "Walther T.C."xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19608861 | http://purl.uniprot.org/core/name | "Science"xsd:string |