| http://purl.uniprot.org/citations/19608878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19608878 | http://www.w3.org/2000/01/rdf-schema#comment | "Wound healing and inflammation are both significantly reduced in mice that lack gammadelta T cells. Here, the role of epithelial intercellular adhesion molecule-1 (ICAM-1) in gammadelta T cell migration in corneal wound healing was assessed. Wild-type mice had an approximate fivefold increase in epithelial gammadelta T cells at 24 hours after epithelial abrasion. ICAM-1(-/-) mice had 50.9% (P < 0.01) fewer gammadelta T cells resident in unwounded corneal epithelium, which failed to increase in response to epithelial abrasion. Anti-ICAM-1 blocking antibody in wild-type mice reduced epithelial gammadelta T cells to a number comparable to that of ICAM-1(-/-) mice, and mice deficient in lymphocyte function-associated antigen-1 (CD11a/CD18), a principal leukocyte receptor for ICAM-1, exhibited a 48% reduction (P < 0.01) in peak epithelial gammadelta T cells. Re-epithelialization and epithelial cell division were both significantly reduced ( approximately 50% at 18 hours, P < 0.01) after abrasion in ICAM-1(-/-) mice versus wild-type, and at 96 hours, recovery of epithelial thickness was only 66% (P < 0.01) of wild-type. ICAM-1 expression by corneal epithelium in response to epithelial abrasion appears to be critical for accumulation of gammadelta T cells in the epithelium, and deficiency of ICAM-1 significantly delays wound healing. Since gammadelta T cells are necessary for efficient epithelial wound healing, ICAM-1 may contribute to wound healing by facilitating gammadelta T cell migration into the corneal epithelium."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.090112"xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/author | "Smith C.W."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/author | "Burns A.R."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/author | "Rumbaut R.E."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/author | "Byeseda S.E."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/author | "Dieffenbaugher S."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/pages | "571-579"xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/title | "ICAM-1 is necessary for epithelial recruitment of gammadelta T cells and efficient corneal wound healing."xsd:string |
| http://purl.uniprot.org/citations/19608878 | http://purl.uniprot.org/core/volume | "175"xsd:string |
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