| http://purl.uniprot.org/citations/1961249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1961249 | http://www.w3.org/2000/01/rdf-schema#comment | "CALCIUM is involved in the adaptation of vertebrate photoreceptors to light and may have a similar role in invertebrate phototransduction. But the molecular mechanisms mediating this stimulus-dependent regulation are not well understood in any G protein-coupled transduction system. We have developed a preparation of isolated Drosophila photoreceptors that has allowed us to carry out an electrophysiological characterization of the light-activated response in these sensory neurons using patch-clamp techniques. We report here that extracellular calcium entering through the light-activated conductance is a key regulator of both the activation and deactivation phases of the phototransduction cascade, and that inaC mutant photoreceptors are specifically defective in the calcium-dependent deactivation mechanism. These data suggest that the light-dependent calcium influx inactivates this cascade through a biochemical pathway that requires the inaC gene product, and that this mechanism represents a molecular basis for stimulus-dependent regulation of visual transduction in Drosophila photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.org/dc/terms/identifier | "doi:10.1038/354230a0"xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/author | "Ranganathan R."xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/author | "Zuker C.S."xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/author | "Harris G.L."xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/author | "Stevens C.F."xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/pages | "230-232"xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/title | "A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization."xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://purl.uniprot.org/core/volume | "354"xsd:string |
| http://purl.uniprot.org/citations/1961249 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1961249 |
| http://purl.uniprot.org/citations/1961249 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1961249 |
| http://purl.uniprot.org/uniprot/P13677#attribution-AD3F5D3F1FF1C3C566A0CFF1AEB14B3C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1961249 |
| http://purl.uniprot.org/uniprot/#_P13677-mappedCitation-1961249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1961249 |
| http://purl.uniprot.org/uniprot/P13677 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1961249 |