| http://purl.uniprot.org/citations/19620281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19620281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19620281 | http://www.w3.org/2000/01/rdf-schema#comment | "A critical step during intrathymic T-cell development is the transition of CD4(+) CD8(+) double-positive (DP) cells to the major histocompatibility complex class I (MHC-I)-restricted CD4(-) CD8(+) and MHC-II-restricted CD4(+) CD8(-) single-positive (SP) cell stage. Here, we identify a novel gene that is essential for this process. Through the T-cell phenotype-based screening of N-ethyl-N-nitrosourea (ENU)-induced mutant mice, we established a mouse line in which numbers of CD4 and CD8 SP thymocytes as well as peripheral CD4 and CD8 T cells were dramatically reduced. Using linkage analysis and DNA sequencing, we identified a missense point mutation in a gene, E430004N04Rik (also known as themis), that does not belong to any known gene family. This orphan gene is expressed specifically in DP and SP thymocytes and peripheral T cells, whereas in mutant thymocytes the levels of protein encoded by this gene were drastically reduced. We generated E430004N04Rik-deficient mice, and their phenotype was virtually identical to that of the ENU mutant mice, thereby confirming that this gene is essential for the development of SP thymocytes."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00793-09"xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00793-09"xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Kobayashi A."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Kobayashi A."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Satoh R."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Satoh R."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Miura I."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Miura I."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Wakana S."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Wakana S."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Kawamoto H."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Kawamoto H."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Fukiage H."xsd:string |
| http://purl.uniprot.org/citations/19620281 | http://purl.uniprot.org/core/author | "Fukiage H."xsd:string |