| http://purl.uniprot.org/citations/19620306 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19620306 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factors mediating the development of CD1d-restricted invariant NKT (iNKT) cells remain incompletely described. Here, we show that loss of the AP-1 transcription factor Fra-2 causes a marked increase in the number of both thymic and peripheral iNKT cells, without affecting the development of other T-lineage cells. The defect is cell-autonomous and is evident in the earliest iNKT precursors. We find that iNKT cells expressing the lower affinity TCRVbeta8 are proportionally overrepresented in the absence of Fra-2, indicating altered selection of iNKT cells. There is also widespread dysregulation of AP-1-directed gene expression. In the periphery, mature Fra-2-deficient iNKT cells are able to participate in an immune response, but they have an altered response to Ag, showing increased expansion and producing increased amounts of IL-2 and IL-4 compared with their wild-type counterparts. Unusually, naive Fra-2-deficient T cells also rapidly produce IL-2 and IL-4 upon activation. Taken together, these data define Fra-2 as necessary for regulation of normal iNKT cell development and function, and they demonstrate the central role played by the AP-1 family in this lineage."xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803577"xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/author | "Cerundolo V."xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/author | "Weston K."xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/author | "Maurice D."xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/author | "Silk J.D."xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/author | "Lawson V.J."xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/pages | "2575-2584"xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/title | "Aberrant selection and function of invariant NKT cells in the absence of AP-1 transcription factor Fra-2."xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19620306 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19620306 |
| http://purl.uniprot.org/citations/19620306 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19620306 |
| http://purl.uniprot.org/uniprot/P47930#attribution-5B9CE6EC64B07EC26D846D67AAB2DA30 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19620306 |
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