| http://purl.uniprot.org/citations/19622370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19622370 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurons that degenerate in the brains of persons with Alzheimer's disease accumulate mitochondrial amyloid precursor protein (APP), which is thought to negatively affect mitochondrial function and cellular homeostasis. Because proteins that enter mitochondria require assistance from chaperone proteins, we hypothesized that heat-shock proteins (HSPs) help accumulate APP in mitochondria. We found that APP overexpression in N2a cells (APP cells) did not elicit mitochondrial dysfunction. Because cerebral hypoperfusion-associated energy deficiency is an important etiology for Alzheimer's disease, we also challenged the cells with serum starvation. APP/HSP/Bcl-2 complexes formed within the mitochondria of serum-starved APP cells, but not control cells. Mitochondria containing APP/HSP/Bcl-2 complexes induced apoptosis. We hypothesize that APP/HSP/Bcl-2 complexes diminish the functional capacities of HSPs and Bcl-2, which leads to mitochondrial injury and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mad.2009.07.002"xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/author | "Kuo Y.M."xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/author | "Hsu C.T."xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/author | "Yang T.T."xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/name | "Mech Ageing Dev"xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/pages | "592-601"xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/title | "Amyloid precursor protein, heat-shock proteins, and Bcl-2 form a complex in mitochondria and modulate mitochondria function and apoptosis in N2a cells."xsd:string |
| http://purl.uniprot.org/citations/19622370 | http://purl.uniprot.org/core/volume | "130"xsd:string |
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