| http://purl.uniprot.org/citations/19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19627982 | http://www.w3.org/2000/01/rdf-schema#comment | "The let-7 microRNA (miRNA) regulates developmental timing at the larval-to-adult transition in Caenorhabditis elegans. Dysregulation of let-7 results in irregular hypodermal and vulval development. Disrupted let-7 function is also a feature of human lung cancer. However, little is known about the mechanism and co-factors of let-7. Here we demonstrate that ribosomal protein RPS-14 is able to modulate let-7 function in C. elegans. The RPS-14 protein co-immunoprecipitated with the nematode Argonaute homolog, ALG-1. Reduction of rps-14 gene expression by RNAi suppressed the aberrant vulva and hypodermis development phenotypes of let-7(n2853) mutant animals and the mis-regulation of a reporter bearing the lin-41 3'UTR, a well established let-7 target. Our results indicate an interactive relationship between let-7 miRNA function and ribosomal protein RPS-14 in regulation of terminal differentiation that may help in understanding the mechanism of translational control by miRNAs."xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2009.07.011"xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://purl.uniprot.org/core/author | "Slack F.J."xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://purl.uniprot.org/core/author | "Chan S.P."xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19627982 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://purl.uniprot.org/core/pages | "152-160"xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://purl.uniprot.org/core/title | "Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://purl.uniprot.org/core/volume | "334"xsd:string |
| http://purl.uniprot.org/citations/19627982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19627982 |
| http://purl.uniprot.org/citations/19627982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19627982 |
| http://purl.uniprot.org/uniprot/#_A0A131MBH5-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_A0A131MBP2-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_A0A131MBQ6-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_A0A131MCR0-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_P52819-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_P52821-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_A0A131MCW2-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_A0A131MD37-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_A8WHN2-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_A8WIR1-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_O18240-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_O18650-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |
| http://purl.uniprot.org/uniprot/#_P34334-mappedCitation-19627982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19627982 |