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http://purl.uniprot.org/citations/19628565http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19628565http://www.w3.org/2000/01/rdf-schema#comment"

Background

Platelet-derived growth factors (PDGFs) and vascular endothelial growth factors and their receptors [platelet-derived growth factor receptors (PDGFRs) and vascular endothelial growth factor receptors (VEGFRs)] are related to both angiogenesis and lymphangiogenesis and are important targets in new cancer treatment strategies. We aimed to study the PDGFs/PDGFRs and correlations with lymph node metastasis (LNM) and investigate the prognostic impact of the co-expression of PDGF-B and VEGFR-3 and its correlation with LNM.

Patients and methods

Tumor tissue samples from 335 resected patients with stage I-IIIA non-small-cell lung cancer (NSCLC) were obtained and tissue microarrays were constructed from duplicate cores of tumor cells and tumor-related stroma from each specimen. Immunohistochemistry was used to evaluate the expression of the molecular markers PDGF-A, PDGF-B, PDGF-C, PDGF-D, PDGFR-alpha, PDGFR-beta, VEGFR-3 and D2-40.

Results

There were 232 N0 and 103 N+ patients (76 N1 and 27 N2). In multivariate analyses, high tumor cell PDGF-A expression (P = 0.017) correlated with LNM. Tumor cell co-expression of VEGFR-3 and PDGF-B correlated with nodal metastasis and was an independent indicator of poor prognosis (hazard ratio 4.8, confidence interval 95% 2.80-8.31, P < 0.001).

Conclusion

Tumor cell PDGF-A expression correlates with LNM, and the co-expression of PDGF-B and VEGFR-3 is strongly associated with poor survival in NSCLC patients."xsd:string
http://purl.uniprot.org/citations/19628565http://purl.org/dc/terms/identifier"doi:10.1093/annonc/mdp296"xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/author"Al-Saad S."xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/author"Bremnes R.M."xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/author"Busund L.T."xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/author"Al-Shibli K."xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/author"Donnem T."xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/name"Ann Oncol"xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/pages"223-231"xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/title"Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer."xsd:string
http://purl.uniprot.org/citations/19628565http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/19628565http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19628565
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