| http://purl.uniprot.org/citations/19631370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19631370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19631370 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling (MAVS) proteins mediate IFN production in response to cytosolic double-stranded RNA or single-stranded RNA containing 5'-triphosphate (5'-ppp). Cytosolic B form double-stranded DNA, such as poly(dA-dT)*poly(dA-dT) [poly(dA-dT)], can also induce IFN-beta, but the underlying mechanism is unknown. Here, we show that the cytosolic poly(dA-dT) DNA is converted into 5'-ppp RNA to induce IFN-beta through the RIG-I pathway. Biochemical purification led to the identification of DNA-dependent RNA polymerase III (Pol-III) as the enzyme responsible for synthesizing 5'-ppp RNA from the poly(dA-dT) template. Inhibition of RNA Pol-III prevents IFN-beta induction by transfection of DNA or infection with DNA viruses. Furthermore, Pol-III inhibition abrogates IFN-beta induction by the intracellular bacterium Legionella pneumophila and promotes the bacterial growth. These results suggest that RNA Pol-III is a cytosolic DNA sensor involved in innate immune responses."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.06.015"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.06.015"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/author | "Chiu Y.-H."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/author | "Chiu Y.-H."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/author | "Macmillan J.B."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/author | "Macmillan J.B."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/pages | "576-591"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/pages | "576-591"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/title | "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/title | "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway."xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/19631370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19631370 |
| http://purl.uniprot.org/citations/19631370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19631370 |
| http://purl.uniprot.org/citations/19631370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19631370 |
| http://purl.uniprot.org/citations/19631370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19631370 |